Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis.
نویسندگان
چکیده
Chronic Fatigue and/or Fibromyalgia have long been diseases without definition. An explanatory model of coagulation activation has been demonstrated through use of the ISAC panel of five tests, including, Fibrinogen, Prothrombin Fragment 1+2, Thrombin/ AntiThrombin Complexes, Soluble Fibrin Monomer, and Platelet Activation by flow cytometry. These tests show low level coagulation activation from immunoglobulins (Igs) as demonstrated by Anti-B2GPI antibodies, which allows classification of these diseases as a type of antiphospholipid antibody syndrome. The ISAC panel allows testing for diagnosis as well as monitoring for anticoagulation protocols in these patients.
منابع مشابه
بررسی شیوع سندرم فیبرومیالژی در بیماران مراجعه کننده به درمانگاه داخلی بیمارستان دکتر شریعتی درسال1384
Background: Fibromyalgia has been defined as a constellation of complaints including diffuse chronic pain and the presence of tender points. Its frequency varies from 3% to 20%. This study was conducted to estimate the prevalence of fibromyalgia syndrome in patients who come to the general medical clinic of Dr. Shariati hospital.Methods: Using a standard questionnaire, all patients who came to ...
متن کاملنشانگان آنتی فسفولیپید
Antiphospholipid syndrome is an autoimmune condition characterized by recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with moderate to high levels of antiphospholipid antibodies. Most of clinical features are results of thrombotic phenomena. The pathophysiologic basis ot this syndrome is still unknown. the diagnosis of this syndrome is made by combination of clinic...
متن کاملQuality of life in fibromyalgia syndrome referred to clinic of Physical Medicine and Rehabilitation in Baqiyatallah Hospital, Tehran
Background & Purpose: Fibromyalgia syndrome is a chronic disease with unknown etiology musculoskeletal pain and tender points throughout the body are numerous. The aim of this study was to measure quality of life in patients with fibromyalgia syndrome that referred to Physical Medicine and Rehabilitation clinic in Baqiyatallah Hospital. Methods & Materials: Patients that referred to Physical...
متن کاملمعرفی و بررسی یک مورد بیمار مبتلا به سندرم آنتی فسفولیپید آنتی بادی در زمینه لوپوس سیستمیک، با تظاهر اولیه کره
Manifestation of chorea in patients with systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APA synd.) is not common. Moreover, primary presentation of the disease with chorea is rare and only few such cases are reported in literature in recent years. We report here the case of a 28 year old woman who was first seen at the age of 10 with clinical manifestations of chorea...
متن کاملRevisiting Beta 2 Glycoprotein I, the Major Autoantigen in the Antiphospholipid Syndrome
Beta 2 glycoprotein I (β2GPI) is a single chain 50 kDa highly glycosylated glycoprotein at an approximate concentration of 4 μM in cells. The abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. In addition, β2GPI has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
دوره 10 7 شماره
صفحات -
تاریخ انتشار 1999